# Known-report review — demonstration

In this randomized ancillary study, 25,871 adults received vitamin D3 (2,000 IU/day) or placebo within a factorial design. For first total fracture, the hazard ratio was 0.98 (95% CI 0.89–1.08). This finding does not demonstrate equivalence. Fracture adjudication was blinded, although ascertainment began with participant reports. Only one dose was tested; participants were not selected for vitamin D deficiency. Extrapolation to deficiency treatment or institutionalized populations is therefore limited. [LeBoff et al., Methods, Results and Discussion](https://pmc.ncbi.nlm.nih.gov/articles/PMC9716639/).

This AI-assisted reading covers one report. It is not a systematic evidence synthesis or treatment recommendation. The linked matrix locates the extracted result; the search log preserves the failed title query and successful identifier lookup. The supplement, raw participant data and a comprehensive notice search were not assessed. No independent reviewer or complete risk-of-bias instrument is claimed.